|What Motivates the Adolescent? Brain Regions Mediating Reward Sensitivity across.|
|Van Leijenhorst, L.; Zanolie, K.; Van Meel, C. S.; Westenberg, P.M.; Rombouts, S. A. R. B.; Crone, E. (2010)|
The relation between brain development across adolescence and adolescent risky behavior has attracted increasing interest in recent years. It has been proposed that adolescents are hypersensitive to reward because of an imbalance in the developmental pattern followed by the striatum and prefrontal cortex. To date it is unclear if adolescents engage in risky behavior because they overestimate potential rewards or because they respond more to received rewards and whether these effects occur in the absence of decisions. In this study, we used an fMRI paradigm that allowed us to dissociate effects of the anticipation, receipt and omission of reward in 10-12, 14-15, and 18-23 year-old participants. We show that in anticipation of uncertain outcomes the anterior insula is more active in adolescents compared to young adults, and that the ventral striatum shows a reward related peak in middle adolescence, whereas young adults show orbitofrontal cortex activation to omitted reward. These regions show distinct developmental trajectories. This study supports the hypothesis that adolescents are hypersensitive to reward, and adds to the current literature in demonstrating that neural activation differs in adolescents even for small rewards in the absence of choice. These findings may have important implications for understanding adolescent risk-taking behavior.